Endocrine Abstracts

Aim: Has testosterone undecanoat 1000 mg intramuscular injection (NebidoR; Bayer), 1 at 3month, negative effect on prostate? For this purpose, we appreciate the prostatic volume (see Pisoschi, this congress) and PSA (this study) in hypogonadic patients after testosterone injection up to 11 years.Material and method: A. PSA (ng/ml) was done in Bucharest accredited laboratories.B. Patients: PSA analysis was done before tre...

Aim: Re-Analysing (study starting in 2007) the effect of injectable testosterone undecanoat depot (TUD) in hypogonadic patients.Material-method: A. Patients: at onset 278 men with hypogonadism (median: 61 y).B. Distribution: by decade (starting with 20y); no =6, 17, 25, 70, 86, 55, 18, 1.C. TUD (NebidoR-Bayer) 1000 mg injected one/3 months i.m.D. Prostate volume (PV) apprecia...

AbstractAim and objectives: To investigate the prevalence of relationships between kin/relatives with a known thyroid immune disorder related to Hashimoto thyroiditis.Material and method: 1. Thyroid disease diagnosis: a. ATPO > 34 u/ml = Hashimoto thyroiditis (HT); b. ATPO = normal but with high antithyroglobuline (ATG) = thyroiditis with only hyper-ATG (T-ATG); c. hypothyroidism without high ATPO/ATG = idiopat...

Aim: The biological diagnostic of Hashimoto thyroiditis (HT) is based on higher than normal levels of antithyroperoxydase antibodies (ATPO). Our goal was to establish the cut-off limit of normality (the upper limit) for ATPO in our thyroid normal patients. This limit and not that of the laboratory, should be used as diagnosis of Hashimoto thyroiditis.Material and method: 1. ATPO was investigated in patients with normal level of thyroid hormones (euthyroi...

Aim: Re-analysing the effect of injectable testosterone undecanoate depot (TUD) in hypogonadic patients.Materials and method: (A) Patients: at onset 210 men with hypogonadism (median age: 61.5 years). (B) Distribution: by decade; n=4, 12, 21, 54, 59, 43, 16, and 1. (C) TUD (NebidoR-Bayer-Schering) 1000 mg was injected one per 3 months i.m. (D) Prostate volume (PV) appreciated by per-abdominal ultrasound: 3.5 MHz probe, elliptical volume (cm...

Aim: To find if testosterone undecanoate (TUD) 1000 mg injection (NebidoR; Bayer-Schering) at 3 months has a negative effect on prostate.Materials and method: i) PSA (ng/ml) registred before (T0) and after TUD at T1 (2 weeks) to T10 (7 years) (see Pisoschi, this Congress); ii) statistical analysis: t-test, simple correlation, and multiple regression.Results: (A) Patients at onset: 143 men, 18–96 years, average: 60.38;...

Aim: Most research teams analyze the evolution of patients with Hashimoto thyroiditis (HT) on syndromal basis, not on pathogenetic basis. Thus, most researchers refer to thyroid function evolution. In this study we tried to show how evolve the antithyroid antibodies. Therefore, we analyzed ATPO evolutive patterns.Method: (1) ATPO levels were analyzed in several accreditated Bucharest laboratories. (2) Only patients with minimum 3 investigations were cons...

Background: Hashimoto thyroiditis (HT) is defined as thyroid chronic inflammation due to high level antithyroperoxydase antoantibodies (ATPO) and/or antithyroglobuline autoantibodies (ATG) and their destructive process on thyroid cell. The diagnostic uses specific and very characteristic ultrasound features. What diagnosis has to have those patients with ultrasound features of HT, who are hypothyroid, but with normal levels of ATPOs and normal levels of ATGs ?<p c...

Introduction: Testosterone therapy in elderly is controversial, because of the effect on prostate. The old age itself is not a contraindication in the therapy of hypogonadism.Aim: We analyze the effect of 24 months of therapy with testosterone undecanoat depot (1000 mg/4 ml) (TUD) on the volume of the prostate (VP).Patients and method: The patients were 79 symptomatic hypogonadic men, with normal value of PSA (<4 g/l). The urol...

Introduction: Sorafenib, an orphan medication, is an oral protein kinase inhibitor, used in the treatment of hepatic, advanced renal and breast cancer, or metastatic iodine-refractary thyroid cancer. The drug also inhibits angiogenesis, and VEGF, having a dual effect on the tumor cells as well as on the tumor vasculature.Aim: We present a case with hyperthyroidism, as adverse effect of the therapy with sorafenib, but with no markers of thyroid autoimmuni...